Antonio Valencia and David Cotterill provide the goals to win three on the trot in pre-season.
This was the first chance Latics fans had a chance to see Chris Hutchings' new look Latics on English soil as they took on the newly promoted Championship side at Bloomfield Road, and they carried on where they left off after their successful tour of Holland last week by winning again.
Hutchings named a strong line-up with Mario Melchiot captain at right back, and with a new look defensive partnership of Andreas Granqvist and Titus Bramble.
David Cotterill was on the right wing, whilst Paul Scharner and Antonio Valencia were in middle of the park, and the creative Jason Koumas was given a run on the left flank.
Former Wigan midfielder Mike Flynn was given a start by the Tangerines following his summer move from Gillingham.
Latics opened the scoring on 19 minutes when Valencia saw his right-footed shot beat 'Pool goalkeeper Paul Rachubka.
The lead should have been doubled just before the break though, when Julius Aghahowa got onto the end of a Koumas free-kick and hit the crossbar, before the Nigerian hit the rebound, but the 'keeper pushed the ball away to safety.
However, Mike Pollitt made a brilliant save at the other end of the pitch as he denied Keigan Parker.
But the hosts did equalise on 51 minutes when a defensive mix-up led to Ben Burgess netting an equaliser. It was the first goal Latics had conceded during the summer.
Latics restored their lead thirteen minutes later when Cotterill's shot was deflected off Latvian defender Kaspars Gorkks and the ball deceived Rachubka.
Latics: Pollitt, Melchiot, Granqvist (Boyce 58), Bramble (Hall 75), Kilbane, Cotterill, Scharner, Koumas (Baines 58), Valencia, Heskey, Aghahowa (Folan 75).
Unused: Saunders, landzaat, Montrose, Moore, Cywka, Dunne.