Lopez, McManaman and Fyvie start for Latics as Nathan Ellington returns to the town for Crewe Alexandra.
Latics: Marosi, Campabadal, Boothman, Buxton, Lopez, Morris, Chow, Fyvie, McManaman, Johnson, R,Watson
Subs: Cottrill, Orsula, Bingham, Ainscough, Sumner
Crewe: Martin, Tootle, White, Nolan, Ray, Gorman, West, Turton, Ellington, Clayton, Colclough
Subs: Appleton, Wilson, Waters
After 20 days without a competitive fixture Wigan Athletic's Under 21s are back in action today against Crewe Alexandra at the Robin Park Arena.
It's Latics' second home game in a row as they remain unbeaten as hosts, with their last fixture a 2-2 draw with Leeds United.
Graham Barrow and Dennis' Lawrence's side start the game in seventh place in the Professional Development League Two North, level on points with both Birmingham and Leeds directly above them and one point behind Nottingham Forest and Huddersfield Town, meaning a victory this afternoon could lift them as high as third.
Crewe are two places behind Latics but five points worse off.
The reverse fixture at Crewe's training ground finished 1-1 with Danny Redmond equalising late on.
Kick off for today's game is 2:00pm with admission prices at £4.65 for adults and £2.70 for concessions.
You can follow the game live with us via the Cover It Live service below, or follow major incidents and goals on Twitter