Roberto Martinez makes one change from the side that started in the 3-0 win at Villa Park on Saturday with James McArthur coming in for David Jones.
Wigan Athletic: Al Habsi, Kone, McCarthy, Caldwell (Capt), Di Santo, Maloney, McArthur, Boyce, Ramis, Beausejour, Figueroa
Subs: Pollitt, Jones, Gomez, McManaman, Boselli, Stam, Golobart.
Manchester United: De Gea, Rafael, Evra, Ferdinand, Evans, Giggs, Hernandez, Carrick, Young, van Persie, Cleverley.
Subs: Lindegaard, Valencia, Smalling, Vidic, Wellbeck, Scholes, Kagawa.