Roberto Martinez makes seven changes from the weekend's game against Fulham.
Adrian Lopez, Callum McManaman and Ryo Miyaichi are all drafted in for their first starts of the season and Slovakian Under 21 international Filip Orsula makes the bench.
West Ham United: Henderson, Spence, Tomkins, McCartney, Potts, Noble, O'Neil, Vaz Te, Jarvis, Maiga, Hall
Subs: Spiegel, Collins, Taylor, Tombides, Fanimo, Driver, McCallum
Wigan Athletic: Al Habsi, Stam, Ramis, Lopez, Caldwell, Figueroa, Jones, McArthur, Miyaichi, McManaman, Boselli
Subs: Pollitt, Boyce, Kone, Watson, Gomez, Fyvie, Orsula