Roberto Martinez is forced to leave out Antolin Alcaraz due to injury but, Jean Beausejour is passed fit leaving Latics unchanged from the side that drew at home to Stoke City last time out.
Man United: Lindegaard, Rafael, Ferdinand, Vidic, Buttner, Nani, Carrick, Scholes, Giggs, Hernandez, Welbeck
Subs: De Gea, Evans, Valencia, Van Persie, Cleverley, Powell, Kagawa
Wigan Athletic: Al Habsi, Boyce, Caldwell, Figueroa, Ramis, Beausejour, McCarthy, McArthur, Maloney, Di Santo, Kone
Subs: Pollitt, Watson, Crusat, Jones, Gomez, Boselli, Miyaichi