Home debut goals from Ryan Shotton and Nick Powell sealed Latics' second home victory in a row as Scott Carson turned in an outstanding performance for his second clean sheet in two matches.
Shotton gave Latics the lead in the first half from a Powell corner, before excellent resolve throughout then ended with Powell scoring a goal of his own courtesy of a goalkeeping error from Ipswich's Dean Gerken.
Owen Coyle made four changes from the side that lined up in Latics' first ever Europa League game on Thursday, as Thomas Rogne, Jean Beausejour, Leon Barnett and Ben Watson returned to the starting XI, with the FA Cup winning goal scorer wearing the captain's armband as Emmerson Boyce moved to the substitutes' bench.
It was a furious pace at the start of the game as within the first few minutes, Ipswich attacked, Latics countered and Ipswich attacked again almost instantly.
The cross bar shuddered just two minutes in as the Tractor Boys gave Latics food for thought when Luke Chambers' header from a corner was clipped onto the bar by the head of Beausejour.
Without a recognised striker on the pitch, the likes of Nick Powell, James McClean and Callum McManaman offered the threat going forward, with the latter skilfully winning a corner down the left hand side on 11 minutes.
Sixty seconds later Powell curled it over towards the back post and on his home debut Ryan Shotton rose above the Ipswich defence to head Latics into the lead.
Latics' chances to extend their lead came just as regularly as Ipswich's chances to equalise.
The first blow was dealt by Latics as McManaman broke free from a quick Carson clearance, he found McClean joining him in the counter attack, but the Republic of Ireland international couldn't find the perfect moment to shoot as Ipswich's defenders sprinted back.
Minutes later Carson blocked a close range effort from Ryan Tunnicliffe, but the ball rolled out to the edge of the area for a second attempt with Watson on hand to throw his body in front of the ball, blocking a goal-bound shot.
McClean then saw a delicate free kick deflected around the foot of the left hand post, before Ipswich's David McGoldrick's front post header did the same at the other end.
A back and forth affair called Carson into action twice in four minutes, first saving from point blank range when Daryl Murphy found himself five yards from goal and secondly pushing a long range Cole Skuse effort around the post.
Latics pushed hard twice towards the end of the first half, with training ground routine seeing Powell comes inches away from a goal on his home debut, before McClean almost volleyed in a McManaman flick on in the last few seconds of added time.
The second half started with a similarly impressive piece of goalkeeping as Carson cut out a low cross from the left, a theme of his impressive performance throughout.
Latics had to dig in and defend resiliently during the second 45 minutes with the back four and goalkeeper constantly aware of the aerial Ipswich threat.
On 64 minutes McManaman almost doubled the lead when space opened up for him inside the area as he latched onto Powell pass from the right, but the winger dragged his effort wide, dropping to the floor in the process, before hobbling off the to be replaced by Roger Espinoza.
As much as Carson had to be on hand to keep Ipswich out, Latics remained dangerous and Powell almost scored with 10 minutes remaining when he dove onto the end of an outswinging Watson free kick, but saw the ball goes agonisingly wide.
Moments later Ipswich tried their hardest to equalise but Latics did their very best to stop them as Thomas Rogne threw himself in front of the ball on the ground as McGoldrick hacked at it during a frantic close range scramble.
A less than solid looking Dean Gerken in the Ipswich goal gave Powell his opportunity to finish of the game as it edged towards the last few minutes, but not before an outstanding piece of goalkeeping once again from Carson as he tipped a long range Christophe Berra effort around the post at full stretch.
Then came the clincher, Powell spotted an opportunity to win the ball and took it as the ball bounced outside of the area with Gerken back-tracking to try and catch it inside the box, instead Powell threw himself at the ball with his head, winning possession and proceeding to walk towards goal and smash in his first for the club.
Fittingly a big goal kick from the games top performer drew time on the game as Latics picked up their second home victory in a row.